The house was designed in 1900 for Mr. and Mrs. William Huff by the noted architect, Ralph Adams Cram. Mr. Cram designed very few houses and is known mainly for his ecclesiastical buildings. Greensburg has two of the Cram’s buildings: the Huff houses now owned by the YWCA Westmoreland County, and the First Presbyterian Church on South Main Street. The original clippings of ivy were brought from Westminster Abbey in London, England.

Some changes to the building had to be made to meet city and state safety regulations for use as a public building. The dedication and hard work of many volunteers enabled the YWCA to turn the house into an appropriate headquarters for the YWCA.

The building was dedicated on September 12, 1970. The Program Center incorporates a new reception room which links the two structures, a large multi-purpose room with a cathedral ceiling and dormer windows, and a handicapped accessible restroom on its upper level. Outside, a walkway links the lower level to the Used Bookstore and fenced playground and then connects to the sidewalk going to the front of the original headquarters building, the Huff house.